Testing anti-ageing supplements may uncover answer to healthy life | Science & Tech News

Clinical trials on anti-ageing supplements may uncover the answer to remaining healthy in later life, an expert has said.

While many supplements are readily available and inexpensive, there is a lack of evidence to show if they are effective, said Professor Cynthia Kenyon, an ageing expert.

Clinical trials may reveal that one supplement, already in circulation, holds the secret to slowing down the biological ageing process, and in turn, age-related diseases like cancer and dementia.

Prof Kenyon, who works for Google subsidiary, Calico Life Sciences, and whose research revolutionised the scientific understanding of ageing, said trials on rapamycin and metformin – two supplements that have been linked to anti-ageing – are needed in particular.

Rapamycin was originally developed as an immunosuppressant for organ transplant patients, while metformin is used controls glucose production in type 2 diabetics.

Professor Cynthia Kenyon speaking at the Frontiers Forum 2023
Professor Cynthia Kenyon speaking at a science conference in Switzerland

She also called for other substances found in red wine and sperm to be tested.

“A clinical trial that’s large enough to be meaningful costs millions of dollars,” Prof Kenyon said. “And so there’s no business model for this because if you want a clinical trial with something that’s freely available and inexpensive, you can’t recoup your cost of the trial.

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“And yet it’s an important need for the world because if they work and make you more resilient, not only do these interventions slow down ageing, but they counteract age-related disease also.

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The science of ageing

“So you would make people – if they work – resilient and more disease-resistant, and they can be sold to everyone, poor people can be given them.”

She added that knowing which supplements work on humans would be “wonderful for the world”.

Prof Kenyon called for the World Health Organisation (WHO), governments, non-profit groups and philanthropists to get together and start human trials.

“We don’t know if any of them will work, but you find out,” she said.

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